Pre-clinical pharmacokinetic-pharmacodynamic modelling and biodistribution studies of donepezil hydrochloride by a validated HPLC method
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چکیده
منابع مشابه
Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride.
Cinacalcet hydrochloride (cinacalcet) is a calcimimetic approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) receiving dialysis and for the treatment of hypercalcaemia in patients with parathyroid carcinoma. Following oral administration, peak plasma concentrations of cinacalcet occur within 2-6 hours. The absolute bioavailability is 20-25%, ...
متن کاملPharmacokinetic and pharmacodynamic profile of donepezil HCl following evening administration.
AIMS The primary objective of this study was to characterize the pharmacokinetics and pharmacodynamics of single daily doses of donepezil (5 and 10 mg) each evening for 28 consecutive days. A secondary objective was to measure the plasma protein binding of donepezil at steady state. METHODS This was a double-blind, randomized, multiple-dose study in healthy male (n=13) and female (n=3) volunt...
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The antibiotic residues in milk are a well-known serious problem and pose several health hazards to consumers. We have described a simple, rapid, and inexpensive DLLME-HPLC/UV technique for the extraction of chloramphenicol and florfenicol residues in milk samples. Under the optimum conditions, linearity of the method was observed over the range 0.02-0.85 µg/L with correlation coefficients > 0....
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The antibiotic residues in milk are a well-known serious problem and pose several health hazards to consumers. We have described a simple, rapid, and inexpensive DLLME-HPLC/UV technique for the extraction of chloramphenicol and florfenicol residues in milk samples. Under the optimum conditions, linearity of the method was observed over the range 0.02-0.85 µg/L with correlation coefficients > 0....
متن کاملHPLC-UV Analysis of Phloretin in Biological Fluids and Application to Pre-Clinical Pharmacokinetic Studies
Phloretin [3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan1-one] is a hydrophobic, dihydrochalcone, polyphenolic compound (MW 274.3 g/mol, XlogP 2.6) that has been identified in apples and other natural sources including Pieris japonica, Kalmia latifolia, Hoveniae Lignum, and Loiseleuria procumbens [1-6] (Figure 1). Phloridzin is the glycoside of phloretin (phloretin-2’-glucose) which has ...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2018
ISSN: 2046-2069
DOI: 10.1039/c8ra03379j